Vitamin B12 is crucial for maintaining healthy nerve tissue and preventing cognitive decline. However, a recent study suggests that even “normal” levels of B12 might not be enough to protect against neurological damage, particularly in older adults.
Vitamin B12, or cobalamin, is found in animal products, certain dry fruits, nutritional yeast, and fortified foods. A deficiency can lead to serious health issues like megaloblastic anemia and neurological problems. Symptoms include sensory ataxia, weakness, and cognitive impairment.
In the U.S., a B12 deficiency is defined as a blood level below 148 pmol/L. However, clinical features often guide supplementation decisions due to disagreements on what constitutes a deficiency.
The study involved 231 healthy participants with a median age of 71. It used advanced tests like multifocal visual evoked potentials (mfVEP) to assess neurological health. The results showed that lower levels of bioavailable B12, specifically Holo-TC, were linked to slower nerve conduction and decreased spatial processing speed.
These findings highlight the need to redefine optimal B12 levels, as current standards may not prevent cognitive decline. The study suggests that even within normal ranges, low bioavailable B12 can lead to neurological dysfunction, emphasizing the importance of revising nutritional guidelines.
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