Parkinson’s disease, a neurological disorder that affects millions globally, is linked to both genetic and environmental factors. A new study published in Science has revealed the structure of the human PINK1 protein, which plays a vital role in preventing neuronal damage—crucial in the development of Parkinson’s.
PINK1’s Role in Protecting Cells
PINK1 protects mitochondria, the energy sources in cells, by marking damaged ones for removal. When PINK1 is mutated, it fails to remove defective mitochondria, leading to cellular toxins that kill brain cells—ultimately causing Parkinson’s disease.
New Insights into PINK1 Activation
Researchers used human cells and cryo-electron microscopy to observe PINK1’s activation process. The study identified how PINK1 detects mitochondrial damage, attaches to it, and signals for its removal through a protein called ubiquitin.
Implications for Treatment
This discovery brings researchers closer to developing drugs that could enhance PINK1 activity, potentially offering a breakthrough in treating Parkinson’s. Experts believe targeting PINK1 could help slow or stop disease progression, although more research is needed for clinical application.
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