Collagen supplements are everywhere—touted for glowing skin, joint health, and even weight loss. But could they also help people with ulcerative colitis (UC)? A new study from China suggests collagen peptides (small protein fragments from animal collagen) might one day become a therapy for this inflammatory gut condition.
What the Study Found
Researchers tested fish-derived collagen peptides in lab-grown cells and mice with UC-like inflammation. The results, published in npj Science of Food, showed:
- In lab cells, collagen reduced inflammation.
- In mice, collagen lowered harmful gut bacteria, repaired colon damage, and strengthened the gut barrier. Treated mice also had milder UC symptoms than untreated ones.
While promising, lead researcher Yan Wang of Yanbian University cautions: “Human trials are needed before we can confirm collagen’s benefits for UC patients.”
Could Collagen Help You
Experts stress that mouse results don’t guarantee human success. Still, some dietitians see potential. Jenna Volpe, R.D.N., notes collagen’s anti-inflammatory amino acids (like glycine) and prebiotic effects may support gut health. However, she warns:
Not a cure: Collagen shouldn’t replace medications or doctor-approved treatments.
Mixed results: Some UC patients improve; others feel worse. “Every gut is unique,” says Volpe.
How to Try Collagen Safely
Before taking collagen:
Consult your doctor: especially if you have UC.
Start slow: Volpe recommends 1 tsp (5g) daily, increasing gradually to 15–30g if tolerated.
Mix it in: Add powder to coffee, smoothies, or yogurt, or try capsules/gummies.
The Bottom Line
Collagen peptides show early potential for UC, but more research is needed. Always work with a healthcare provider to find what’s best for your gut.
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