Exposure to “forever chemicals” during pregnancy could pose significant health risks later in life, a new study suggests.
A recent long-term analysis indicates that exposure to per- and polyfluoroalkyl substances (PFAS), commonly known as “forever chemicals” due to their persistence in the environment, may increase the likelihood of obesity and associated health problems. These synthetic compounds, used in everyday products such as non-stick cookware, dental floss, and water-resistant clothing, can accumulate in the body and the environment, raising concerns about their potential impact on health.
The study tracked 547 pregnant women in the United States who were initially free from diabetes and had detectable levels of six different PFAS in their blood samples, including PFOS, a common chemical used for stain and grease resistance. After an average follow-up period of 17.7 years, researchers observed that women with higher concentrations of certain PFAS had greater body fat and higher weights compared to those with lower levels.
This increase in body fat could elevate the risk of obesity and its related conditions, including heart disease and certain cancers. Jordan Burdeau, a PhD researcher in epidemiology at Harvard University and one of the study’s authors, emphasized that the findings support the notion that pregnancy may be a critical period for PFAS exposure, potentially leading to long-term weight gain and adverse cardiometabolic health outcomes.
Previous research has also linked PFAS exposure to various health issues, including thyroid disease, liver damage, and developmental problems in infants. Additionally, studies on the same cohort found an association between PFAS exposure and higher chances of experiencing high blood pressure during pregnancy.
However, the study does have limitations. The sample predominantly consisted of well-educated, white women from the US, which may not represent other demographic groups. Furthermore, the plasma samples were collected between 1999 and 2002, a period before some PFAS were phased out. While PFOS has been restricted in the European Union for over a decade, it is still present in some products.
Despite these limitations, Burdeau noted that the study could enhance our understanding of how PFAS exposure during pregnancy affects long-term health, potentially leading to improved prevention and early detection strategies for cardiometabolic issues in women.
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